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Table 2 Type I errors (95 % confidence intervals) of family-based sequence kernel association test in the family-based, population-based, and the combined data, and of meta-analytic approach

From: On combining family- and population-based sequencing data

Gene Family Population Combined Meta-analysis
MAP4 0.050 (0.024–0.090) 0.100 (0.062–0.150) 0.085 (0.050–0.133) 0.095 (0.058–0.144)
TNN 0.030 (0.011–0.064) 0.080 (0.046–0.127) 0.085 (0.050–0.133) 0.125 (0.083–0.179)
NRF1 0.050 (0.024–0.090) 0.070 (0.039–0.115) 0.080 (0.046–0.127) 0.065 (0.035–0.109)
LEPR 0.040 (0.017–0.077) 0.045 (0.021–0.084) 0.080 (0.046–0.127) 0.055 (0.028–0.096)
FLT3 0.090 (0.054–0.139) 0.060 (0.031–0.102) 0.060 (0.031–0.102) 0.070 (0.039–0.115)
ZFP37 0.045 (0.021–0.084) 0.045 (0.021–0.084) 0.060 (0.031–0.102) 0.110 (0.070–0.162)
CGN 0.040 (0.017–0.077) 0.060 (0.031–0.102) 0.070 (0.039–0.115) 0.105 (0.066–0.156)
MTRR 0.035 (0.014–0.071) 0.030 (0.011–0.064) 0.065 (0.035–0.109) 0.075 (0.043–0.121)
SLC35E2 0.085 (0.050–0.133) 0.065 (0.035–0.109) 0.090 (0.054–0.139) 0.100 (0.062–0.150)
ZNF443 0.075 (0.043–0.121) 0.060 (0.031–0.102) 0.050 (0.024–0.090) 0.070 (0.039–0.115)
RAI1 0.035 (0.014–0.071) 0.090 (0.054–0.139) 0.080 (0.046–0.127) 0.095 (0.058–0.144)
PTTG1IP 0.070 (0.039–0.115) 0.080 (0.046–0.127) 0.095 (0.058–0.144) 0.110 (0.070–0.162)
CABP2 0.055 (0.028–0.096) 0.090 (0.054–0.139) 0.090 (0.054–0.139) 0.130 (0.087–0.185)
ZNF544 0.045 (0.021–0.084) 0.080 (0.046–0.127) 0.090 (0.054–0.139) 0.095 (0.058–0.144)
REPIN1 0.065 (0.035–0.109) 0.050 (0.024–0.090) 0.075 (0.043–0.121) 0.080 (0.046–0.127)
GTF2IRD1 0.080 (0.046–0.127) 0.075 (0.043–0.121) 0.060 (0.031–0.102) 0.080 (0.046–0.127)
FLNB 0.050 (0.024–0.090) 0.070 (0.039–0.115) 0.095 (0.058–0.144) 0.120 (0.078–0.173)
GSN 0.065 (0.035–0.109) 0.055 (0.028–0.096) 0.055 (0.028–0.096) 0.105 (0.066–0.156)
LRP8 0.065 (0.035–0.109) 0.050 (0.024–0.090) 0.135 (0.091–0.190) 0.105 (0.066–0.156)
PSMD5 0.025 (0.008–0.057) 0.080 (0.046–0.127) 0.080 (0.046–0.127) 0.090 (0.054–0.139)
GAB2 0.030 (0.011–0.064) 0.065 (0.035–0.109) 0.065 (0.035–0.109) 0.105 (0.066–0.156)
ABTB1 0.075 (0.043–0.121) 0.075 (0.043–0.121) 0.100 (0.062–0.150) 0.125 (0.083–0.179)
KRTAD11-1 0.070 (0.039–0.115) 0.055 (0.028–0.096) 0.050 (0.024–0.090) 0.055 (0.028–0.096)
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BMC Proceedings

ISSN: 1753-6561

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