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|
SNP panel
|
Weight
|
Common SNPs
|
Rare SNPs
|
Joint tests
|
|---|
|
MAF >5 %
|
MAF ≤5 %
|
Default
|
WS
|
Fisher
|
|---|
|
NSNP
|
p value
|
NSNP
|
p value
|
p value
|
p value
|
p value
|
|---|
|
AGTR1 with no flanking region, positions 148415571–148460795
|
|
GWAS
|
equal
|
11
|
0.189
|
7
|
0.097
|
0.177
|
0.102
|
0.101
|
|
1/ν
|
11
|
0.113
|
7
|
0.050
|
0.054
|
0.044
|
0.043
|
|
SEQ
|
equal
|
74
|
0.203
|
138
|
0.060
|
0.173
|
0.076
|
0.076
|
|
1/ν
|
74
|
0.160
|
138
|
0.098
|
0.083
|
0.088
|
0.090
|
|
AGTR1 with 30 kb flanking region, positions 148385571–148490795
|
|
GWAS
|
equal
|
30
|
0.100
|
12
|
0.072
|
0.092
|
0.050
|
0.052
|
|
1/ν
|
30
|
0.045
|
12
|
0.069
|
0.030
|
0.029
|
0.029
|
|
SEQ
|
equal
|
198
|
0.053
|
300
|
0.067
|
0.047
|
0.030
|
0.032
|
|
1/ν
|
198
|
0.039
|
300
|
0.172
|
0.045
|
0.044
|
0.050
|
|
AGTR1 with 500 kb flanking region, positions 147915571–148960795
|
|
GWAS
|
equal
|
277
|
0.206
|
51
|
0.048
|
0.196
|
0.061
|
0.065
|
|
1/ν
|
277
|
0.151
|
51
|
0.064
|
0.102
|
0.059
|
0.066
|
|
SEQ
|
equal
|
2170
|
0.192
|
2244
|
0.069
|
0.173
|
0.080
|
0.085
|
|
1/ν
|
2170
|
0.157
|
2244
|
0.051
|
0.062
|
0.057
|
0.060
|
|
AGTR1 containing LD-block, positions 148344702–148568958
|
|
GWAS
|
equal
|
80
|
0.058
|
19
|
0.076
|
0.055
|
0.035
|
0.036
|
|
1/ν
|
80
|
0.040
|
19
|
0.114
|
0.034
|
0.036
|
0.039
|
|
SEQ
|
equal
|
499
|
0.029
|
592
|
0.106
|
0.027
|
0.027
|
0.030
|
|
1/ν
|
499
|
0.027
|
592
|
0.112
|
0.025
|
0.026
|
0.030
|
- Association of AGTR1 with real SBP was tested with a linear kernel on minor allele dosage data for GWAS and sequence (SEQ); p ≤0.05 bold. NSNP common and rare SNPs, respectively, were combined into joint tests: kernel K
all
(default), weighted sum test (WS), and Fisher’s p value pooling for correlated p values
