The 1-monolaurin inhibit growth and eradicate the biofilm formed by clinical isolates of Staphylococcus epidermidis

Table 2 The inhibition biofilm formation of 1-monolaurin or rifampicin on S. epidermidis clinical isolates

S. epidermidis clinical isolate	TSB Media	Compound	Concentration (μg/mL)	OD ± SD			BIC (%)	BIC50 (μg/mL)	BIC80 (μg/mL)
+	+	O	–	0.454	±	0.040	0	–	–
O	+	O	–	0.081	±	0.003	100	–	–
+	+	5% of DMSO	–	0.456	±	0.020	−0.537	–	–
+	+	1-monolaurin	1000	0.071	±	0.032	102.773	26.669	166.688
			500	0.093	±	0.040	96.780
			250	0.163	±	0.013	77.996
			125	0.240	±	0.200	57.424
			62.5	0.226	±	0.194	61.181
			31.25	0.248	±	0.025	55.277
			15.625	0.288	±	0.024	44.365
			7.813	0.362	±	0.036	24.597
			3.906	0.375	±	0.033	21.109
			1.953	0.375	±	0.013	21.119
+	+	Rifampicin	250	0.075	±	0.003	101.699	0.079	0.974
			125	0.090	±	0.009	97.764
			62.5	0.098	±	0.008	95.349
			31.25	0.094	±	0.001	96.601
			15.625	0.105	±	0.007	93.560
			7.813	0.094	±	0.001	96.422
			3.906	0.099	±	0.009	95.170
			1.953	0.116	±	0.008	90.698
			0.977	0.191	±	0.050	70.483
			0.488	0.188	±	0.011	71.288

ISSN: 1753-6561